. Author manuscript; available in PMC: 2019 Feb 1.

Published in final edited form as: Circ Cardiovasc Qual Outcomes. 2018 Feb;11(2):e004227. doi: 10.1161/CIRCOUTCOMES.117.004227

Table 3. Coronary Artery Disease Consortium (CADC) model statistics.

Performance measure	CADC Model^*	CADC Model with troponin^*
Overall
Coefficient of Discrimination	0.230	0.257
Brier score	0.163	0.159
Discrimination
C-statistic [95% CI]	0.788 [0.758-0.819]	0.800 [0.770-0.830] ^†
Calibration (Hosmer-Lemeshow Test)
Chi-square	16.84	14.30
P-value	0.032	0.074
NRI (Categorical) [95% CI]		0.062 [0.035 - 0.089]
Statistics at 10% PTP threshold
Sensitivity [95% CI]	0.944 [0.916-0.971]	0.940 [0.912-0.969] p=0.655
Specificity [95% CI]	0.375 [0.337-0.411]	0.440 [0.403-0.478] p<0.001
PPV [95% CI]	0.376 [0.339-0.412]	0.401 [0.363-0.439] p<0.001
NPV [95% CI]	0.944 [0.916-0.971]	0.949 [0.924-0.973] p=0.518

CADC, Coronary Artery Disease Consortium; CI, confidence interval; NRI, net reclassification improvement; PTP, pre-test probability; PPV, positive predictive value; NPV, negative predictive value;

both models apply updated intercept determined from SCOT-HEART population

^†

p = 0.0039 that true difference in AUC is not equal to 0.