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. Author manuscript; available in PMC: 2018 Aug 21.
Published in final edited form as: Nature. 2018 Feb 21;555(7694):117–120. doi: 10.1038/nature25502

Fig. 3. Structure of Htt domains.

Fig. 3

a, N-HEAT domain. The insertion between N-HEAT repeat 6 and 7 is shown in green, with the unresolved sequence as a dashed line. b, C-HEAT domain, with the insertions between HEAT repeats shown in green (between C-HEAT repeats 1 and 2) and teal (between C-HEAT repeats 2 and 3). c, Bridge domain. In a-c helices forming part of tandem repeats are shown as rods in similar colors, and other helices as ribbons. At the top right of a-c, the part of Htt shown in each panel is highlighted in the Htt-HAP40 map using the color code of Fig. 2. d, Back view of Htt highlighting the interaction region (inset) between loops of N- and C-HEAT. The unresolved sequence at the C-terminus of the bridge domain is shown as a yellow dashed line.