Figure 4.

Cartilage Depth Measurements: Increase in cartilage depth during proliferative phase (14 weeks) is attributable to increase in articular cartilage superficial to the tidemark. a. Sample total cartilage depth measurement: Using a touchscreen pen, cartilage depth was traced in 20 different places by each reviewer. Each reviewer attempted to evenly space depth measurement throughout the slide. b. Osteomeasure screen shot of total cartilage depth schematic showing where the depth measurements were taken for this particular slide. c. Articular Cartilage Depth: depth from articular surface to tidemark in microns is significantly higher at 14 weeks (the proliferative stage) than at all other time points. At 45 weeks, depth was significantly less than it was at baseline or at 14 weeks. d. Total Cartilage depth is significantly greater during proliferative phase than at all other time points, significantly less at 29 and 45 weeks than at baseline and 14 weeks. This change is attributable to changes in the articular cartilage rather than the mineralized cartilage. (Note: Control = 45wk uninjured).