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. 2018 Feb 21;14(2):e1006871. doi: 10.1371/journal.ppat.1006871

Fig 10. Heatmap of the global liver transcriptomic signature.

Fig 10

The liver transcriptome was evaluated by microarray analysis. Treatment groups (SIV+ or SIV+ cART) were compared against age-matched uninfected macaques to determine differentially expressed genes using the limma package in R/bioconductor. Co-expression analysis was performed using weighted gene coexpression network analysis (WGCNA) and heatmap packages in R/bioconductor using cutoffs of 1.5 fold change and 0.05 adjusted pvalues in at least one condition. Gene networks (modules) involved in immune response and inflammation are upregulated in SIV-infected macaques with antiviral RLR and interferon signaling highly upregulated in both adults and infants.