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. 2018 Feb 21;14(2):e1006871. doi: 10.1371/journal.ppat.1006871

Table 4. Top differentially expressed genes in SIV+ ART infant macaques.

Gene Log2 F.C. Adj p-value Gene Ontology
Akr1b7 3.687 0.0358 cellular lipid metabolism, oxidation-reduction process,
AKR1B10 3.671 0.0243 farnesol catabolism, oxidation-reduction process, retinoid metabolism
SREBF1 2.298 0.0221 cellular response to fatty acid, cholesterol metabolism, insulin signaling, lipid metabolism
UCHL1 2.205 0.0007 cell proliferation, protein deubiquitination
NQO1 1.777 0.0333 removal of superoxide free radicals, response to toxic substances, xenobiotic metabolism
ACSS2 1.597 0.0651 lipid biosynthesis, mitochondrion organization
CTSE 1.466 0.0028 antigen processing and presentation via MHC class II, protein catabolism
STARD4 1.331 0.0366 cholesterol import/intracellular transport, regulation of bile acid biosynthesis
SEMA4D 1.052 0.0221 cell adhesion, immune response, regulation of cell migration, regulation of leukocyte aggregation
NANOS2 1.003 0.0109 cell differentiation, mRNA catabolism
PRDX1 1.000 0.0480 cellular response to oxidative stress, hydrogen peroxide catabolism
NR1D2 1.000 0.0904 lipid homeostasis, regulation of lipid metabolism, energy homeostasis
VAX2 0.944 0.0074 Wnt signaling, regulation of transcription from RNA polymerase II promoter
SLC9A3R1 0.869 0.0368 Wnt signaling, bile acid secretion, regulation of cell proliferation and migration
PAFAH1B3 0.850 0.0221 lipid metabolism
EMC9 0.848 0.0366 protein binding
SENP2 0.793 0.0096 Wnt signaling, protein destabilization, regulation of protein ubiquitination
ABHD4 0.765 0.0232 lipid catabolism, phophatidylethanolamine acyl-chain remodeling
NPC1L1 0.760 0.0109 response to drug, cholesterol biosynthesis, intestinal cholesterol and lipid absorption
BLVRB 0.714 0.0232 heme catabolism, oxidation-reduction process