Fig. 6. The miR-338-5p level is negatively correlated with the ABCB1 and EGFR mRNA levels in HCC clinical samples.

a–c The expression of miR-338-5p, ABCB1, and EGFR were detected by qRT–PCR. d The expression of ABCB1 mRNA was inversely associated with the miR-338-5p expression in the HCC tissues. e The correlation between the expression of EGFR mRNA and miR-338-5p in the HCC tissues. Student’s t-test (two-tailed) or Spearman’s correlation test was used to analyze the data. Data in all experiments are presented as the means ± SD of three independent experiments. *P < 0.05, **P < 0.01 vs. non-tumor tissues