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. 2018 Feb 16;7:16. doi: 10.1038/s41426-018-0034-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Therapeutic regimens of four CHB patients. Patient 1, 2, and 3 had combination of PEG-IFN with nucleoside analogs while patient 4 had PEG-IFN treatment alone. b Serum HBsAg levels, HBs-specific B cells and serum HBsAb titers before (white column) and after (black column) PEG-IFN treatment of these 4 patients were displayed. ETV entecavir, ADV adefovir dipivoxil, LAM lamivudine, TDF tenofovir