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. 2018 Jan 10;7:3. doi: 10.1038/s41426-017-0005-x

Fig. 4. Maternal immunization with EV-D68 VLPs provided complete protection for neonatal mice against lethal challenge.

Fig. 4

One-day-old ICR mice born to dams immunized with EV-D68 VLPs or the control antigen were i.p. injected with 1.2 × 105 TCID50 of US/MO/14-18947. All infected mice were observed daily for a survival and b clinical score for 14 days. Clinical scores were graded as follows: 0, healthy; 1, lethargy and reduced mobility; 2, limb weakness; 3, limb paralysis; 4, death. The numbers of mice in each group were shown in brackets