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. 2018 Jan 24;7:8. doi: 10.1038/s41426-017-0011-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Severe cases. b Mild cases. c Age distribution of HFMD mild and severe cases from 2012 to 2016 in Shanghai. As CV-A6 and CV-A10 was not detected for further EV-serotype identification until 2013, the untyped EV for 2012–2016 shown here may include CV-A6 and CV-A10 infections