Table 6.

Net reclassification index and integrated discrimination improvement statistics for individual biomarkers over Framingham risk variables, body mass index, and statin use

	Five-year mortality			Ten-year mortality
	Index	95% CI	P-value	Index	95% CI	P-value
TIMP-1
NRI	0.28	0.21–0.36	<0.0000	0.19	0.14–0.26	<0.0000
NRI for events	0.02	−0.04 to 0.08		0.01	−0.03 to 0.04
NRI for non-events	0.27	0.22–0.30		0.19	0.15–0.23
IDI	0.027	0.019–0.036	<0.0000	0.02	0.01–0.02	<0.0000
hsCRP
NRI	0.19	0.12–0.28	<0.0000	0.11	0.05–0.17	0.013
NRI for events	0.07	0.02–0.15		0.01	−0.02 to 0.04
NRI for non-events	0.12	0.08–0.16		0.10	0.06–0.14
IDI	0.006	0.002–0.01	<0.0000	0.003	0.001–0.007	0.003
eGFR
NRI	0.12	0.04–0.20	0.0014	0.07	0.01–0.13	0.02
NRI for events	−0.05	−0.12 to 0.01		−0.05	−0.08 to − 0.02
NRI for non-events	0.17	0.13–0.22		0.12	0.08–0.16
IDI	0.12	0.007–0.02	<0.0000	0.007	0.004–0.01	<0.0000
MMP-9
NRI	0.01	−0.07 to 0.07	0.8590	0.01	−0.06 to 0.06	0.87
NRI for events	−0.27	−0.33 to − 0.20		−0.25	−0.28 to − 0.20
NRI for non-events	0.27	0.23–0.31		0.25	0.19–0.28
IDI	0.0006	−0.1 to 0.08	0.32	0.0004	−0.0001 to 0.001	0.17

NDI, net reclassification index; IDI, integrated discrimination improvement.