Table 2.
GO Term Enrichment Analysis of DEGs in the Brain
| GO Term | 0.3nM PCB126 | 1.2nM PCB126 | Adjusted p-value |
|---|---|---|---|
| Upregulated genes | |||
| GO:0005261 Cation channel activity | 27 | 25 | 4.52E-06 |
| GO:0000982 Transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | 10 | 9 | 1.62E-03 |
| GO:0043565 Sequence specific DNA binding | — | 18 | 2.20E-02 |
| GO:0019905 Syntaxin binding | 9 | — | 4.81E-02 |
| GO:0005096 GTPase activator activity | 13 | — | 5.00E-02 |
| Downregulated genes | |||
| GO:0003735 Structural constituent of ribosome | 23 | 51 | 1.85E-43 |
| GO:0003723 RNA binding | — | 35 | 6.04E-09 |
| GO:0005518 collagen binding | 6 | — | 2.34E-04 |
| GO:1901681 sulfur compound binding | 10 | — | 2.03E-02 |
| GO:0005546 phosphotidylinositol-4,5-bisphosphate binding | 3 | — | 2.75E-02 |
| GO:0015379 potassium:chloride symporter activity | — | 2 | 3.19E-02 |
Only significantly enriched GO child terms are shown. The number of up and downregulated genes represented under each GO term are listed for both PCB126 concentrations. The list of gene names associated with each GO term is provided in the Supplementary Material (PathwayAnalysis_up.xlsx; PathwayAnalysis_down.xlsx). A dash (—) indicates that the indicated GO term was not significantly enriched in that exposure group.