Table 3.
KEGG Pathway Analysis of DEGs in the Brain
| KEGG ID | KEGG Pathway | 0.3 nM PCB126 | 1.2 nM PCB126 | Adjusted p-value |
|---|---|---|---|---|
| Upregulated genes | ||||
| 04020 | Calcium signaling pathway | 20 | 21 | 1.25E-06 |
| 04010 | MAPK signaling pathway | 23 | 23 | 4.44E-06 |
| 04330 | Notch signaling pathway | 12 | — | 5.61E-06 |
| 00310 | Lysine degradation | 8 | 8 | 2.36E-04 |
| 04012 | ErbB signaling pathway | 6 | 8 | 6.43E-03 |
| 04912 | GnRH signaling pathway | 12 | 6 | 7.04E-03 |
| 04320 | Dorso-ventral axis formation | 6 | 5 | 7.80E-03 |
| 04914 | Progesterone-mediated oocyte maturation | 8 | 6 | 9.52E-03 |
| 04068 | FoxO signaling pathway | 15 | — | 1.13E-02 |
| Downregulated genes | ||||
| 00190 | Oxidative phosphorylation | 64 | 20 | 7.90E-61 |
| 03010 | Ribosome | 31 | 71 | 2.01E-46 |
| 01100 | Metabolic pathways | 124 | — | 4.93E-13 |
| 01200 | Carbon metabolism | 23 | — | 7.18E-04 |
| 04512 | ECM-receptor interaction | 15 | — | 3.04E-03 |
| 00480 | Glutathione metabolism | 8 | — | 3.67E-03 |
| 01212 | Fatty acid metabolism | 11 | — | 1.08E-02 |
| 00020 | Citrate cycle (TCA cycle) | 5 | — | 1.27E-02 |
KEGG pathway analysis of DEGs from 0.3 and 1.2 nM PCB groups was conducted using gProfiler and the enriched KEGG terms were compared using gCocoa. KEGG pathways and the number of up and downregulated DEGs associated with each KEGG term from both treatments are listed below. The list of gene names associated with each pathway is provided in Supplementary Material (PathwayAnalysis_up.xlsx; PathwayAnalysis_down.xlsx). A dash (—) indicates that the KEGG term was not significantly enriched in that exposure group.