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. 2017 Sep 9;160(2):386–397. doi: 10.1093/toxsci/kfx192

Table 5.

List of DEGs Associated With KEGG Term Calicum Signaling

0.3 nM PCB126
1.2 nM PCB126
Gene symbol Gene description logFC FDR logFC FDR
cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.71 0.00012 0.56 0.0025
cacna1g calcium channel, voltage-dependent, T type, alpha 1G subunit 0.73 0.00013 0.54 0.0045
tacr1a tachykinin receptor 1a 0.89 0.00036 0.67 0.0082
cacna1ba calcium channel, voltage-dependent, N type, alpha 1B subunit, a 0.53 0.00172 0.40 0.0365
adcy1a adenylate cyclase 1a 0.64 0.00197 0.59 0.0076
slc8a4a solute carrier family 8 (sodium/calcium exchanger), member 4a 0.55 0.00202 0.53 0.0055
cacna1ab calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b 0.83 0.00394 0.63 0.0326
cacna1da calcium channel, voltage-dependent, L type, alpha 1D subunit, a 0.58 0.00457 0.56 0.0093
erbb4a erb-b2 receptor, tyrosine kinase 4a 0.64 0.00479
chrm2a cholinergic receptor, muscarinic 2a 0.56 0.00691 0.71 0.0018
grm5a glutamate receptor, metabotropic 5a 0.49 0.00753 0.83 0.0001
cacna1ha calcium channel, voltage-dependent, T type, alpha 1H subunit, a 0.45 0.01142 0.43 0.0243
grm1b glutamate receptor, metabotropic 1b 0.76 0.01179
adcy2a adenylate cyclase 2a 0.47 0.01439 0.40 0.0486
cacna1bb calcium channel, voltage-dependent, N type, alpha 1B subunit, b 0.43 0.01621 0.43 0.0215
cacna1i calcium channel, voltage-dependent, T type, alpha 1l subunit 0.50 0.02267 0.55 0.0172
gna11b guanine nucleotide binding protein (G protein), alpha 11b (Gq class) 0.41 0.02381 0.40 0.0394
hrh1 histamine receptor H1 1.14 0.02435
gnas GNAS complex locus 0.40 0.02603
itpr1b inositol 1,4,5-triphosphate receptor, type 1b 0.42 0.02829
atp2b3b ATPase, Calcium transporting, plasma membrane 3b 0.55 0.0224
nos1 nitric oxide synthase 1 (neuronal) 0.69 0.0027
slc8a2b solute carrier family 8 (sodium/calcium exchanger), member 2b 0.54 0.0389
trhrb thyrotropin-releasing hormone receptor b 0.85 0.0360
trhra thyrotropin-releasing hormone receptor a 0.82 0.0149
stim2b stromal interaction molecule 2b 0.52 0.0473

A dash (—) indicates that the gene was not differentially expressed in that exposure group.