Table 1.
Measurements in the Healthy Aging Longitudinal Study in Taiwan (HALST)
| Type | Measures | Instruments |
|---|---|---|
| Interviewer-administered home visit | ||
| Questionnaires | Physical functioning | Barthel Index, Lawton-Brody IADL Scale |
| Frailty | CHS frailty phenotype, the Edmonton frail scale, CSHA-CFA, SOF | |
| Cognitive function | MMSE | |
| Mental health | 20-item CES-D | |
| Health-related quality of life | SF-12 | |
| Diet assessment | FFQ | |
| Others: evaluation of general conditions, social demography, health conditions, geriatric conditions (fall, pain), chronic disease risk factor, sleep, use of healthcare, lifestyle (smoking, alcohol, betel, physical activity, nutritional supplements) and family history of chronic diseases | ||
| Physical assessment | Performance-based measures | Peak flow test, grip strength, SPPB |
| Clinical examination | ||
| Examinations | Anthropometry | Height and weight, and hip circumference |
| Brief physical examination | ||
| Lower extremity function | Single-leg stand test, timed up-and-go test, 6-min walk | |
| Cardiovascular function | Blood pressure, heart rate, electrocardiogram, ankle-brachial index measurement, heart rate variability | |
| Cognitive function | Digit symbol substitution test, clock drawing test | |
| Vision | Visual acuity | |
| Mental health | PRIME-MD | |
| Questionnaires | Clinical assessment of cardiovascular symptoms | Rose questionnaire, TIA questionnaire |
| Other: vision, hearing, incontinence | ||
| Laboratory analysis | ||
| Blood tests | Routine biochemistry | Cholesterol, triglyceride, HDLC, LDLC, globulin, albumin, total protein, AST, ALT, GGT, insulin, glucose, creatinine, BUN, uric acid |
| Haematology | HbA1c, complete blood count (RBC, WBC, platelet), haemoglobin, HCT, MCV, MCH, MCHC, differential count of WBC | |
| Inflammation-related | High-sensitivity CRP (hsCRP), intact PTH, ionized calcium, vitamin B12, folic acid | |
| Hepatitis virus titre | HBsAg, Anti-HCVAb | |
| Coagulation factor | D-dimer, fibrinogen | |
| DNA | Genes associated with ageing (SNPs) | |
| Other | IL-6, TNF-R1, IGF-1, sIL-6r, vitamin D | |
| Urine test | Routine urinalysis | Colour, clarity, specific gravity, pH, glucose, protein, occult blood, urobilinogen, bilirubin, nitrite, ketone body, RBC, WBC, epithelial cells, casts, crystals, bacteria, parasites, urinary albumin, urine creatinine, leukocyte esterase |
| Follow-up telephone questionnaire | ||
| Questionnaires | Self-rated health status, physical functioning, pain, weight changes, smoking, physical activity, vision, falls and fractures, depressive symptoms, new events and health conditions, specific examinations and surgeries | BSRS-5 |
IADL, Instrumental Activity of Daily Living; CHS, Cardiovascular Health Study; CSHA-CFA, Chinese-Canadian Study of Health and Ageing Clinical Frailty scale physical version; SOF, Study of Osteoporotic Fractures; MMSE, Mini-Mental State Examination; CES-D, Center for the Epidemiologic Studies Depression Scale; SF-12, Short Form 12; FFQ, Food Frequency Questionnaire; SPPB, Short Physical Performance Battery; PRIME-MD, Primary Care Evaluation of Mental Disorders; TIA, transient ischaemic attack; HDLC, high-density lipoprotein cholesterol; LDLC, low-density lipoprotein cholesterol; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma-glutamyl transpeptidase; BUN, blood urea nitrogen; HbA1c, glycated haemoglobin; RBC, red blood cells; WBC, white blood cells; HCT, haematocrit; MCV, mean cell volume; MCH, mean corpuscular haemoglobin; MCHC, mean corpuscular haemoglobin concentration; CRP, C-reactive protein; PTH, parathyroid hormone; HBsAg, hepatitis B surface antigen; Anti-HCVAb, anti-hepatitis C virus antibody; IL-6, interleukin-6; TNF-R1, tumour necrosis factor-R1; IGF-1, insulin-like growth factor-1; SNPs, single nucleotide polymorphisms; sIL-6r, soluble interleukin-6 receptor; BSRS-5, Brief Symptom Rating Scale-5.