Table 3b.

Odds ratios (and 95% confidence intervals) for developing gastric cancer for those individuals by serum concentration of cholecystokinin (continuous and quartile models)

Group	Cholecystokinin: continuous, log				Cholecystokinin: quartiles							Ptrend
					Q1	Q2		Q3		Q4
	OR		95% CI	P-value		OR	95% CI	OR	95% CI	OR	95% CI
Gastric cancer (n = 264)
Age-adjusted	0.80	0.70, 0.92		0.002	REF	1.09	0.75, 1.56	0.53	0.35, 0.82	0.72	0.48, 1.07	0.006
Adjusted	0.85	0.73, 0.99		0.033	REF	1.13	0.74, 1.70	0.60	0.37, 0.96	0.79	0.50, 1.22	0.063
Adj. + gastrin	0.84	0.72, 0.98		0.028	REF	1.11	0.73, 1.70	0.58	0.35, 0.93	0.77	0.49, 1.21	0.056
Gastric non-cardia adenocarcinoma (n = 200)
Age-adjusted	0.80	0.69, 0.93		0.004	REF	1.08	0.72, 1.62	0.48	0.30, 0.79	0.75	0.49, 1.16	0.020
Adjusted	0.85	0.72, 1.01		0.054	REF	1.16	0.74, 1.82	0.56	0.33, 0.96	0.83	0.51, 1.35	0.126
Adj. + gastrin	0.85	0.72, 1.01		0.054	REF	1.13	0.72, 1.80	0.53	0.31, 0.93	0.80	0.49, 1.31	0.096
Oesophagogastric junctional adenocarcinoma (n = 57)
Ag-adjusted	0.84	0.65, 1.09		0.185	REF	0.97	0.48, 1.96	0.72	0.34, 1.56	0.67	0.30, 1.47	0.182
Adjusted	0.85	0.64, 1.13		0.266	REF	0.96	0.46, 2.01	0.77	0.34, 1.74	0.69	0.30, 1.60	0.331
Adj. + gastrin	0.86	0.64, 1.13		0.285	REF	1.01	0.48, 2.15	0.75	0.32, 1.76	0.73	0.32, 1.70	0.373
Gastric carcinoid tumours (n = 3)
Age adjusted	0.66	0.34, 1.31		0.236	REF	0.57; 0.27, 1.22						0.127

Adjusted for: age at randomization, total years of smoking and total cigarettes/day, alcohol (g/day), BMI (kg/m²), fruit intake (g/day), vegetable intake (g/day), education (post-primary school), Helicobacter pylori (+/-) and ATBC treatment group assignment; additional adjustment as indicated for gastrin.

REF, reference value.