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Schematic of a proposed tiered approach for the application of omics data and the AOP concept with the ultimate goal to derive computational models that enable assessment of species sensitivity to chemicals of regulatory concern in support of ERA. ADME, absorption, distribution, metabolism, and excretion of a chemical in an organism; KE, key event; MIE, molecular initiating event; TK, toxicokinetics; TD, toxicodynamics.
