Table 3.
Pathway Analysis of Concordant Dose-Responsive Genes in Mouse Liver and Kidney Following Treatment With TCE or PCE as Illustrated in Figure 4
| Category | Term | Count | pValue | qValuea |
|---|---|---|---|---|
| Pathway significantly (q < 0.05) positively correlated with TCE dose in both liver and kidney (Figure 4A)b | ||||
| KEGG_PATHWAY | mmu03320:PPAR signaling pathway | 5 | 3.7E-07 | 5.5E-06 |
| Pathways significantly (q < 0.05) negatively correlated TCE dose in both liver and kidney | ||||
| None | ||||
| Pathways significantly (q < 0.05) positively correlated with PCE dose in both liver and kidney (Figure 4B)c | ||||
| GOTERM_CC_DIRECT | GO:0005777 ∼ peroxisome | 7 | 3.4E-07 | 2.2E-05 |
| GOTERM_BP_DIRECT | GO:0006637 ∼ acyl-CoA metabolic process | 5 | 6.2E-07 | 1.9E-04 |
| Pathways significantly (q < 0.05) negatively correlated PCE dose in both liver and kidney | ||||
| None | ||||
Representative pathways for each annotation cluster are shown, complete lists of significant pathways and clusters are included in Supplementary Tables 10 and 11.
a
Benjamini-Hochberg-corrected P value.
b
Full list of the significant pathways is in Supplementary Table 10.
c
Full list of the significant pathways is in Supplementary Table 11.