Table 1. Summary of known NTRK, ALK and ROS1 fusion proteins.

Gene	Fusion partner	Malignancy	PMID	Reference
NTRK1	NFASC	Glioblastoma Multiforme	24261984	Shah et al. (2013)
	BCAN	Glioblastoma Multiforme	24261984	Shah et al. (2013)
	TPM3	Diffuse Intrinsic Pontine Glioma	24705251	Wu et al. (2014)
	MPRIP	Lung Adenocarcinoma	24162815	Vaishnavi et al. (2013)
	CD74	Lung Adenocarcinoma	24162815	Vaishnavi et al. (2013)
	TPM3	Colorectal Cancer	24962792	Ardini et al. (2014)
	RABGAP1L	Cholangiocarcinoma	24563076	Ross et al. (2014)
	TAF	Papillary Thyroid Carcinoma	8288244	Greco et al. (1993)
	TFG	Thyroid Carcinoma	7565764	Ross et al. (2014)
	LMNA	Spitzoid Melanoma	24445538	Wiesner et al. (2014)
NTRK2	VCL	Diffuse Intrinsic Pontine Glioma	24705251	Wu et al. (2014)
	AGBL4	Diffuse Intrinsic Pontine Glioma	24705251	Wu et al. (2014)
	QKI	Pilocytic Astrocytoma	23817572	Jones et al. (2013)
	NACC2	Pilocytic Astrocytoma	23817572	Jones et al. (2013)
	PAN3	Head and Neck Squamous-Cell Carcinoma	25204415	Stransky et al. (2014)
	TRIM24	Lung Adenocarcinoma	25204415	Stransky et al. (2014)
	AFAP1	Low-Grade Glioma	25204415	Stransky et al. (2014)
	NAV	Low-Grade Glioma	23583981	Zhang et al. (2013)
NTRK3	BTBD1	Diffuse Intrinsic Pontine Glioma	24705251	Wu et al. (2014)
	ETV6	Diffuse Intrinsic Pontine Glioma	24705251	Wu et al. (2014)
	ETV6	Low-Grade Glioma	23583981	Zhang et al. (2013)
	ETV6	Acute Myeloid Leukaemia	21401966	Kralik et al. (2011)
	ETV6	Congenital Fibrosarcoma	9462753	Knezevich et al. (1998b)
	ETV6	Congenital Mesoblastic Nephroma	9823307	Knezevich et al. (1998a)
	ETV6	Secretory Breast Carcinoma	12450792	Tognon et al. (2002)
	ETV6	Thyroid Carcinoma	24327398	Leeman-Neill et al. (2014)
	ETV6	Mammary-Analog Secretory Carcinoma of Salivary Gland Origin	20410810	Skalova et al. (2010)
ALK	ATIC	Anaplastic Large-Cell Lymphoma	10702393	Colleoni et al. (2000)
	CLTC	Anaplastic Large-Cell Lymphoma	12112524	Cools et al. (2002)
	MSN	Anaplastic Large-Cell Lymphoma	11310834	Tort et al. (2001)
	MYH9	Anaplastic Large-Cell Lymphoma	12800156	Lamant et al. (2003)
	NPM	Anaplastic Large-Cell Lymphoma	8122112	Morris et al. (1994)
	RNF213	Anaplastic Large-Cell Lymphoma	22570254	Zhang et al. (2013)
	TFG	Anaplastic Large-Cell Lymphoma	10556217	Hernandez et al. (1999)
	TPM4	Anaplastic Large-Cell Lymphoma	11493472	Meech et al. (2001)
	NPM	Anaplastic Large-Cell Lymphoma	10994999	Drexler et al. (2000)
	NPM	Diffuse Large B-Cell Lymphoma	21474455	Grande et al. (2011)
	CLTC	Diffuse Large B-Cell Lymphoma	12750159	De Paepe et al. (2003)
	SQSTM1	Diffuse Large B-Cell Lymphoma	21134980	Takeuchi et al. (2011)
	NPM	Follicular Lymphoma	21474455	Grande et al. (2011)
	NPM	Hodgkin's Disease	21474455	Grande et al. (2011)
	NPM	Mature B-Cell Neoplasm	21474455	Grande et al. (2011)
	NPM	Peripheral T-Cell Leukaemia	21474455	Grande et al. (2011)
	EML4	Breast Carcinoma	19737969	Lin et al. (2009)
	C2orf44	Colorectal Cancer	22327622	Lipson et al. (2012)
	EML4	Colorectal Cancer	19737969	Lin et al. (2009)
	FN1	Endometrial Stromal Sarcoma	22570254	Ren et al. (2012)
	VCL	Renal-Cell carcinoma	21076462	Debelenko et al. (2011)
	EML4	Lung Adenocarcinoma	17625570, 18927303	Soda et al. (2007); Takeuchi et al. (2008)
	KIF5B	Lung Adenocarcinoma	19383809	Takeuchi et al. (2009)
	KLC1	Lung Adenocarcinoma	22347464	Togashi et al. (2012)
	PTPN3	Lung Adenocarcinoma	22334442	Jung et al. (2012)
	CARS	Inflammatory Myofibroblastic Tumor	13679433	Debelenko et al. (2003)
	CLTC	Inflammatory Myofibroblastic Tumor	11485898	Bridge et al. (2001)
	PPFIBP1	Inflammatory Myofibroblastic Tumor	23957430	Yoshida et al. (2013)
	RANBP2	Inflammatory Myofibroblastic Tumor	12661011	Ma et al. (2003)
	SEC31L1	Inflammatory Myofibroblastic Tumor	16161041	Panagopoulos et al. (2006)
	TPM3	Inflammatory Myofibroblastic Tumor	10934142	Lawrence et al. (2000)
	TPM4	Inflammatory Myofibroblastic Tumor	10934142	Lawrence et al. (2000)
	FN1	Ovarian Carcinoma	22570254	Ren et al. (2012)
	DCTN1	Spitz Nevus/Spitzoid Neoplasms	24445538	Wiesner et al. (2014)
	TPM3	Spitz Nevus/Spitzoid Neoplasms	24445538	Wiesner et al. (2014)
	STRN	Thyroid Carcinoma	24475247	Perot et al. (2014)
ROS1	CEP85L	Angiosarcoma	23637631	Giacomini et al. (2013)
	GOPC	Glioblastoma Multiforme	12661006	Charest et al. (2003b)
	CEP85L	Glioblastoma Multiforme	24261984	Shah et al. (2013)
	SLC34A2	Colorectal Cancer	23719267	Davies and Doebele (2013)
	CD74	Lung Adenocarcinoma	18083107	Davies and Doebele (2013)
	EZR	Lung Adenocarcinoma	23418494, 22327623	Takeuchi et al. (2012)
	LRIG3	Lung Adenocarcinoma	22327623	Takeuchi et al. (2012)
	SDC4	Lung Adenocarcinoma	22327623	Takeuchi et al. (2012)
	TPM3	Lung Adenocarcinoma	22327623	Takeuchi et al. (2012)
	LIMA1	Lung Adenocarcinoma	25264305	Shaw et al. (2014)
	MSN	Lung Adenocarcinoma	25264305	Shaw et al. (2014)
	GOPC	Lung Adenocarcinoma	22661537	Rimkunas et al. (2012)
	SLC34A2	Lung Adenocarcinoma	18083107	Rikova et al. (2007)
	GOPC	Ovarian Carcinoma	22163003	Birch et al. (2011)
	MYO5A	Pigmented Spindle Cell Nevus	24445538	Wiesner et al. (2014)
	PWWP2A	Spitzoid Melanoma	24445538	Wiesner et al. (2014)
	CLIP1	Spitz Nevus/Spitzoid Neoplasms	24445538	Wiesner et al. (2014)
	PPFIBP1	Spitz Nevus/Spitzoid Neoplasms	24445538	Wiesner et al. (2014)
	TPM3	Spitz Nevus/Spitzoid Neoplasms	24445538	Wiesner et al. (2014)
	ZCCHC8	Spitz Nevus/Spitzoid Neoplasms	24445538	Wiesner et al. (2014)
	PPFIBP1	Spitz Nevus/Spitzoid Neoplasms	24445538	Wiesner et al. (2014)
	HLAA	Spitz Nevus/Spitzoid Neoplasms	24445538	Wiesner et al. (2014)
	ERC1	Spitz Nevus/Spitzoid Neoplasms	24445538	Wiesner et al. (2014)
	KIAA1598	Spitz Nevus/Spitzoid Neoplasms	24445538	Wiesner et al. (2014)
	SLC34A2	Gastric Adenocarcinoma	23400546	Lee et al. (2013)