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. 2017 Feb 23;32(9):1493–1503. doi: 10.1093/ndt/gfw454

FIGURE 4.

FIGURE 4

Cardiac expression of FGF23 and FGFR4 correlates with cardiac hypertrophy in uremic rats. In the myocardium of vehicle- and calcitriol-treated 5/6Nx rats, phosphorylation of NFAT (pNFAT) negatively correlates with (A) the cross-sectional area of myocytes and (B) Fgfr4 mRNA levels. (C) The levels of pNFAT as well as mRNA levels of (D) Rcan1 and (E) TRPC6 correlate with cardiac protein levels of full-length Fgf23. The expression of NFAT target genes (F) Rcan1 and (G) TRPC6 negatively correlates with NFAT phosphorylation. N = 59–61 animals.