Figure 5.

Aberrant DNA methylation patterns at CpG rich genomic regions in FMR1− cells. (A) DNA methylation heat map of the static DMCs identified via Contrast 6, which is described in the ‘Materials and methods’ section. Each day of differentiation (D0, D3, D6, D9, D12) for each group is depicted across the x-axis. β-values were averaged for each group. Red = hypermethylation; blue = hypomethylation. (B) Schematic depicting CpG density relative to CpG island (CGI), shore, shelf. CpG density decreases with distance away from islands. (C) Candidate DMCs are preferentially enriched at CpG-dense regions.