Figure 6.

DNA methylation patterns are robust indicators of disease state. (A) WGCNA analysis identified four modules of covariant DMCs correlated with neuronal differentiation (DMC-Blue – Green) and 11 modules correlated with disease state (DMC-Grey – Purple). Modules associated with disease state exhibit inverse patterns between non-disease and FXS FMR1− lines. (B) Chi square distribution of FXS candidate DMC enrichment per DNA methylation module. Red diamonds depict the expected level of candidate DMC enrichment based on module size (i.e. number of DMCs). Bars represent observed values. (C) GREAT was used to assess functional enrichments for each module. The three most significant GO terms for each module are shown. See Supplementary Table 5E for all GO terms for each module. FE = fold enrichment.