Table 6.
Main Effects of Maternal GDM, Preeclampsia, and Obesity during Pregnancy on Global Methylation (%) in t he Placenta Tissues and Cord Blood in the Multivariable Model
| Global Methylation Placenta Tissue |
Global Methylation Umbilical Cord Blood |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Statistics |
Statistics |
|||||||||||
| Unadjusted Model |
Adjusted Model |
Unadjusted Model |
Adjusted Model |
|||||||||
| Maternal Characteristics | B | SE | P Value | B | SE | P Value | B | SE | P Value | B | SE | P Value |
| GDM | 4.34 | 1.25 | 0.001 | 4.47 | 1.22 | 0.003 | 3.45 | 3.27 | 0.30 | 3.72 | 3.44 | 0.29 |
| Preeclampsia | 2.90 | 1.51 | 0.06 | 3.02 | 1.48 | 0.05 | −0.29 | 3.96 | 0.94 | −0.68 | 4.17 | 0.87 |
| Obesity | −2.40 | 0.89 | 0.01 | −2.54 | 0.97 | 0.01 | 0.33 | 2.32 | 0.89 | 1.41 | 2.74 | 0.61 |
Abbreviations: GDM, gestational diabetes mellitus; SE, standard error.
a
In the unadjusted model, no confounders were included. In adjusted models, the effects of sex of the baby, mother's educational attainment at birth of her child, welfare status, marital status, and ethnicity were statistically controlled for. Maternal GDM, preeclampsia, and obesity during pregnancy were analysed in the same model simultaneously.