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. 2017 May 12;32(6):1053–1060. doi: 10.1093/ndt/gfx069

FIGURE 1.

FIGURE 1

Histologic features of native and transplanted kidneys in Patient 1. (A) Renal arterioles of native kidney featured concentric intimal thickening greater than thickness of media and concentric elastic duplication (score = 5; Weigert stain—bar = 40 μm). (B) In the native renal artery several nerves were observed within the adventitia, especially in the area close to the tunica media; nerve diameter ranged from 26 to 121 μm (NFP stain—bar = 100 μm). (C) Evidence of GAP43-positive nerve sprouting was noted in native ganglions close to arterial anastomoses (GAP43 stain—bar = 40 μm). (D–F) In renal nerves of native kidneys, TH-positive sympathetic efferent fibres (D) were more numerous than CGRP-positive sympathetic afferent fibres (E) and NOS-positive parasympathetic fibres (F) (D, bar = 10 μm; E, bar = 5 μm; F, bar = 5 μm). (G) Few GAP43-positive nerve axons could be observed in the renal artery from kidney transplant, distal to arterial anastomosis (GAP43 stain—bar = 100 μm). (H) In transplant renal artery, nerves consisted only of TH-positive sympathetic efferent fibres (TH stain—bar = 10 μm). (Adventitial–medial borders are highlighted by arrows.)