| First choice | Patients with AF and stage III CKD (creatinine clearance 30–49 mL/min) may be treated with apixaban 5 mg twice daily (apixaban 2.5 mg twice a day if ≥1 additional criteria: age ≥80 years, body weight ≤60 kg, serum creatinine ≥ 1.5 mg/dL (133 µmol/L are present), rivaroxaban 15 mg daily, or edoxaban 30 mg once daily |
| Second choice | Dabigatran 110 mg twice daily |
| Not recommended | Dabigatran 150 mg twice daily, rivaroxaban 20 mg once daily, or edoxaban 60 mg once daily |
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