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PCB 11 and its major metabolites increase axonal growth in primary cortical neurons. (A) Representative photomicrographs of DIV 2 cortical neurons after 48 h exposure to vehicle (0.1% DMSO) or varying concentrations of PCB 11, OH-PCB 11, or PCB 11 sulfate. (B) Quantification of axonal length as a percent of control (vehicle). Data presented as the mean ± SE (n = 60–90 neurons from 2 to 3 independent cultures). *P <.05, **P <.01, ***P <.001 relative to vehicle control.
