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. 2017 May 16;158(2):401–411. doi: 10.1093/toxsci/kfx100

Figure 7.

Figure 7

PCB 11 and its major metabolites do not decrease cell viability at concentrations that alter neuronal morphogenesis. Cell viability was assessed in primary cortical (A, C) and hippocampal (B, D) neurons at DIV 9 after 48 h exposure to vehicle (0.1% DMSO) or PCBs by quantifying cellular uptake of calcein AM and propidium iodide (A, B) or LDH release (C, D). Triton X-100 (TX-100, 0.2%) was used as a positive control for each assay. Data presented as the mean ± SE (n = 3 independent cultures). *P <.05, **P <.01, *** P <.001 relative to vehicle control. RFU, relative fluorescence unit.