. 2016 Mar 8;32(2):299–306. doi: 10.1093/ndt/gfw005

Table 3.

ORs and 95% confidence intervals (CIs) associated with modest cognitive impairment (1.0 SD below the mean) for persons in the CKD group (eGFR <60 mL/min/1.73 m²)

Cognitive domain	Neurocognitive test	Zero order		Demographic-adj.^a		Comorbidity-adj.^b
Cognitive domain	Neurocognitive test	OR	95% CI	OR	95% CI	OR	95% CI
Verbal episodic memory	Logic Mem IR	1.73*	[1.10–2.72]	1.14	[0.70–1.85]	1.14	[0.69–1.88]
	Logic Mem DR	1.56	[1.00–2.45]	1.01	[0.63–1.63]	1.01	[0.61–1.66]
	Hopkins VLT	2.74***	[1.84–4.10]	1.66*	[1.07–2.59]	1.48	[0.92–2.36]
Visual-spatial organization/memory	Vis Repro IR	2.87***	[1.91–4.32]	1.67*	[1.06–2.62]	1.41	[0.87–2.29]
	Vis Repro DR	2.80***	[1.87–4.19]	1.43	[0.92–2.24]	1.23	[0.77–1.98]
	Matrix Reasoning	2.40***	[1.63–3.55]	1.40	[0.90–2.20]	1.13	[0.70–1.82]
	Block Design	3.51***	[2.37–5.21]	2.42***	[1.55–3.78]	2.16**	[1.35–3.48]
	Object Assembly	2.86***	[1.92–4.24]	2.03***	[1.32–3.11]	1.82*	[1.15–2.87]
	Hooper VOT	3.20***	[2.07–4.94]	1.72*	[1.06–2.79]	1.59	[0.96–2.65]
Scanning and tracking	Trail Making A^c	2.43***	[1.61–3.69]	1.27	[0.80–2.02]	1.06	[0.65–1.74]
	Trail Making B^c	3.23***	[2.12–4.92]	1.88**	[1.17–3.02]	1.68*	[1.02–2.78]
	Digit Symbol	2.66***	[1.76–4.04]	1.45	[0.90–2.34]	1.15	[0.69–1.93]
	Symbol Search	3.05***	[2.02–4.59]	1.65*	[1.04–2.62]	1.36	[0.83–2.23]
Working memory	Digit Span F	1.61	[0.98–2.63]	1.61	[0.95–2.73]	1.46	[0.84–2.56]
	Digit Span B	1.40	[0.88–2.23]	1.35	[0.81–2.25]	1.24	[0.72–2.13]
	Letter Number	2.10***	[1.34–3.27]	1.23	[0.75–2.00]	0.98	[0.58–1.65]
Abstract reasoning	Similarities	2.23***	[1.48–3.37]	1.74*	[1.07–2.82]	1.66	[1.00–2.75]
Executive functioning	COWA	2.49***	[1.63–3.79]	1.85**	[1.18–2.91]	1.58	[0.98–2.54]
	CLOX 1	1.52	[0.90–2.59]	0.95	[0.54–1.69]	0.88	[0.48–1.63]
	CLOX 2	1.57*	[1.03–2.39]	1.07	[0.68–1.67]	1.02	[0.64–1.64]
General mental state	MMSE	1.64*	[1.01–2.67]	1.12	[0.64–1.93]	1.05	[0.59–1.87]
Language	Boston Naming	1.97**	[1.23–3.15]	1.63	[0.95–2.79]	1.49	[0.85–2.63]

^aDemographic-adjusted model: age, sex, education and race.

^bComorbidity-adjusted model: age, sex, education, race, diabetes, SBP, BMI, cigarettes/week, HDL, CVD, stroke and CRP.

^cLog (base 10).

*P < 0.05.

**P < 0.01.

***P < 0.001.