Figure 1.

Effect of CLOF on concentrations of BAs in livers of male WT and PPARα-null mice. CO or CLOF (300 mg/kg) was administered daily (i.p.) for 4 consecutive days to male WT and PPARα-null mice (n = 6–8 per treatment group). A, Concentrations of ΣBAs and individual BAs were quantified by UPLC-MS/MS. Data represent means ± SEM (n > 5 per group). *p < .05 versus vehicle treatment group. B, The compositions of major BA categories were calculated as the percentage of ΣBAs. Data represent means (n > 5 per group).