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Effect of CLOF on LW and bile flow in WT and PPARα-null mice. CO or CLOF (300 mg/kg) was administered daily (i.p.) for 4 consecutive days to male WT and PPARα-null mice (n = 6-8 per treatment group). On day 5, mice were anesthetized and bile was collected for 40 minutes. LW is expressed as a percent of BW. (A) Bile flow rates were normalized to LW (B) and BW (C). Data represent means ± SEM. Asterisks (*) denote statistically different from vehicle control (p < .05).
