Table 2.
Hazard ratios of aortic valve stenosis by body mass index and waist circumference in the Cohort of Swedish Men and the Swedish Mammography Cohort, 1998–2014
| Men and women |
Men | Women | ||||
|---|---|---|---|---|---|---|
| Casesa | Person-years | Age- and sex-adjusted HR (95% CI) | Multivariable HR (95% CI)b | Multivariable HR (95% CI)b | Multivariable HR (95% CI)b | |
| BMI (kg/m2) | ||||||
| 18.5–22.4 | 178 | 214 801 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| 22.5–24.9 | 353 | 332 244 | 1.16 (0.97–1.39) | 1.13 (0.95–1.36) | 1.16 (0.90–1.51) | 1.12 (0.86–1.44) |
| 25.0–27.4 | 355 | 293 278 | 1.27 (1.06–1.53) | 1.19 (0.99–1.43) | 1.26 (0.97–1.63) | 1.13 (0.86–1.47) |
| 27.5–29.9 | 211 | 147 721 | 1.49 (1.22–1.82) | 1.34 (1.09–1.64) | 1.41 (1.07–1.88) | 1.26 (0.93–1.71) |
| ≥30.0c | 200 | 108 832 | 2.10 (1.72–2.57) | 1.81 (1.47–2.23) | 1.87 (1.39–2.51) | 1.77 (1.32–2.38) |
| P for trend | <0.0001 | <0.0001 | <0.0001 | 0.0001 | ||
| Waist circumferenced | ||||||
| Normal | 350 | 367 296 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Increased | 336 | 295 818 | 1.04 (0.90–1.21) | 1.00 (0.86–1.16) | 0.98 (0.81–1.19) | 1.02 (0.80–1.30) |
| Substantially increased | 418 | 249 037 | 1.47 (1.27–1.69) | 1.30 (1.12–1.51) | 1.38 (1.14–1.66) | 1.21 (0.96–1.53) |
| P for trend | <0.0001 | 0.0003 | 0.001 | 0.07 | ||
The number of cases in the waist circumference analysis does not sum up to the total number owing to missing data.
Adjusted for age (time-scale in the Cox model), sex, education (less than high school, high school, or university), smoking status and history (never, past <10 pack-years, past ≥10 pack-years, current <10 pack-years, current 10–19 pack-years, or current ≥20 pack-years), and history of diabetes, hypertension, and hypercholesterolemia.
The median BMI in this category was 31.7 kg/m2 for men and 32.0 kg/m2 for women.
The categories for normal, increased, and substantially increased waist circumference (cm) were respectively <94, 94–101, and ≥102 (median 108) for men and <80, 80–87, and ≥88 (median 96) for women.