Table 3.
Multivariable analyses for prediction of total mortality and cardiac mortality in the MADIT-II population
| Risk predictors | Death |
Cardiac death |
||||
|---|---|---|---|---|---|---|
| HR (95% CI) | X2 | P-value | HR (95% CI) | X2 | P-value | |
| Tx with ICD | 0.66 (0.46–0.95) | 5.0 | 0.026 | 0.57 (0.38–0.85) | 7.7 | 0.006 |
| PRD (deg2), per SD | 1.37 (1.19–1.59) | 17.7 | <0.001 | 1.39 (1.19–1.63) | 16.8 | <0.001 |
| LVEF (%), per SD | 0.91 (0.76–1.09) | 1.0 | 0.313 | 0.89 (0.73–1.08) | 1.4 | 0.245 |
| NYHA class ≥II | 1.08 (0.73–1.60) | 0.2 | 0.694 | 1.16 (0.76–1.78) | 0.5 | 0.500 |
| Diabetes mellitus | 1.17 (0.80–1.72) | 0.7 | 0.407 | 1.25 (0.83–1.89) | 1.2 | 0.281 |
| BUN >25 mg/dl | 2.26 (1.54–3.31) | 17.2 | <0.001 | 2.24 (1.48–3.39) | 14.4 | <0.001 |
| Beta-blockers | 0.63 (0.44–0.92) | 5.8 | 0.016 | 0.62 (0.42–0.93) | 5.3 | 0.022 |
| QRS (s), per SD | 1.42 (1.19–1.69) | 15.2 | <0.001 | 1.42 (1.17–1.71) | 12.8 | <0.001 |
BUN, blood urea nitrogen; HR, hazard ratio; ICD, implantable cardioverter defibrillator; LVEF, left-ventricular ejection fraction; NYHA, New York Heart Association; PRD, periodic repolarization dynamic; Tx, Treatment.