Table 4.
Multivariable analyses for prediction of sudden cardiac death and non-sudden cardiac death in the MADIT-II population
| Risk predictors | Sudden cardiac death |
Non-sudden cardiac death |
||||
|---|---|---|---|---|---|---|
| HR (95% CI) | X2 | P-value | HR (95% CI) | X2 | P-value | |
| Tx with ICD | 0.33 (0.19–0.58) | 14.5 | <0.001 | 1.41 (0.68–2.91) | 0.9 | 0.351 |
| PRD (deg2), per SD | 1.40 (1.13–1.75) | 9.1 | 0.003 | 1.41 (1.10–1.81) | 7.4 | 0.006 |
| LVEF (%), per SD | 0.79 (0.61–1.03) | 3.0 | 0.082 | 1.22 (0.86–1.74) | 1.2 | 0.266 |
| NYHA class ≥II | 1.31 (0.72–2.41) | 0.8 | 0.379 | 1.47 (0.68–3.17) | 0.9 | 0.330 |
| Diabetes mellitus | 1.25 (0.71–2.21) | 0.6 | 0.407 | 1.16 (0.58–2.31) | 0.2 | 0.684 |
| BUN >25 mg/dl | 1.71 (0.96–3.06) | 3.3 | 0.070 | 3.65 (1.79–7.41) | 12.8 | <0.001 |
| Beta-blockers | 0.68 (0.39–1.18) | 1.9 | 0.166 | 0.63 (0.32–1.25) | 1.7 | 0.189 |
| QRS (s), per SD | 1.25 (0.95–1.64) | 2.6 | 0.106 | 1.61 (1.16–2.22) | 8.3 | 0.004 |
BUN, blood urea nitrogen; HR, hazard ratio; ICD, implantable cardioverter defibrillator; LVEF, left-ventricular ejection fraction; NYHA, New York Heart Association; PRD, periodic repolarization dynamic; Tx, Treatment.