Table 3.

Sensitivity, specificity, and net reclassification based on Class I recommendations for statin eligibility among individuals aged 40–75 years in the Copenhagen General Population Study

Model comparison	Sensitivity (%)	Specificity (%)	ΔSensitivity (%)	ΔSpecificity (%)	NRI	c-Statisticsa	P/O
All
Any ASCVD
ESC/EAS	10	95	Ref	Ref	Ref	0.70
ACC/AHA	72	60	62 (P < 0.0001)	−35 (P < 0.0001)	0.27 (P < 0.0001)	0.72 (P < 0.0001)	1.2
Fatal ASCVD
ESC/EAS	11	94	Ref	Ref	Ref	0.80	5.0
ACC/AHA	87	59	76 (P < 0.0001)	−36 (P < 0.0001)	0.40 (P < 0.0001)	0.82 (P = 0.007)
Men
Any ASCVD
ESC/EAS	14	92	Ref	Ref	Ref	0.69
ACC/AHA	83	43	70 (P < 0.0001)	−49 (P < 0.0001)	0.21 (P < 0.0001)	0.71 (P < 0.0001)	1.4
Fatal ASCVD
ESC/EAS	13	92	Ref	Ref	Ref	0.75	5.1
ACC/AHA	89	41	75 (P < 0.0001)	−50 (P < 0.0001)	0.26 (P = 0.001)	0.77 (P = 0.01)
Women
Any ASCVD
ESC/EAS	6	97	Ref	Ref	Ref	0.70
ACC/AHA	58	73	52 (P < 0.0001)	−24 (P < 0.0001)	0.28 (P < 0.0001)	0.71 (P < 0.0001)	0.9
Fatal ASCVD
ESC/EAS	7	97	Ref	Ref	Ref	0.84	4.0
ACC/AHA	84	72	77 (P < 0.0001)	−25 (P < 0.0001)	0.52 (P = 0.0001)	0.85 (P = 0.18)

^ac-Statistics for discrimination between events and non-events using US-PCE and European-SCORE.

NRI,  net reclassification index; ESC/EAS,  European Society of Cardiology/European Atherosclerosis Society; ACC/AHA, American College of Cardiology/American Heart Association; ASCVD, atherosclerotic cardiovascular disease; P/O, predicted/observed events using European-SCORE and US-PCE.