Table 2.
Primary and secondary outcomes in analysable patients
| AutoPulse (N = 103) | LUCAS (N = 108) | Manual control (N = 126) | Rate difference AutoPulse vs. control (%) (95% CI)a | Rate Difference LUCAS vs. Control (%) (95% CI)a | |
|---|---|---|---|---|---|
| Resuscitation-related structural visceral damage (primary endpoint) | |||||
| Serious or life-threatening damage, overall, n (%) | 12 (11.7) | 8 (7.4) | 8 (6.3) | 5.3 (−2.2 to 12.8) | 1.0 (-5.5 to 7.6) |
| Out-of-hospital arrest onset, n/N (%) | 6/44 (13.6) | 3/46 (6.5) | 2/48 (4.2) | 9.4 (−2.1 to 21.1) | 2.4 (-6.7 to 11.5) |
| In-hospital arrest onset, n/N (%) | 6/59 (10.2) | 5/62 (8.1) | 6/78 (7.7) | 2.5 (−7.2 to 12.2) | −0.23 (-8.9 to 8.4) |
| Insignificant damage, n (%) | 6 (5.8) | 11 (10.2) | 13 (10.3) | ||
| No damage, n (%) | 85 (82.5) | 89 (82.4) | 105 (83.3) | ||
| Serious or life-threatening resuscitation-related visceral damage—detailsb | |||||
| Pneumothorax, n | 6 | 2 | 4 | ||
| Tension pneumothorax, n | 1 | 1 | — | ||
| Pneumomediastinum/oesophagus haematoma, n | 4 | — | — | ||
| Pleural fluid/blood, n | 1 | 3 | 3 | ||
| Lung contusion/haematoma, n | 1 | — | 1 | ||
| Liver rupture, n | 1 | 2 | — | ||
| Intracranial air embolism, n | 1 | — | — | ||
| Pneumoperitoneum, n | — | 1 | — | ||
| Resuscitation-related rib and sternum damage (secondary endpoint) | |||||
| Serious, n (%) | 47 (45.6) | 43 (39.8) | 52 (41.3) | 4.4 (−8.5 to 17.3) | −1.5 (-14.1 to 11.2) |
| Insignificant damage, n (%) | 10 (9.7) | 9 (8.3) | 22 (17.5) | ||
| No damage, n (%) | 46 (44.7) | 56 (51.9) | 52 (41.3) | ||
| Mean number of fractured ribs, mean ± SDc | 8 ± 4 | 8 ± 4 | 7 ± 4 | n.s. | n.s. |
| Sternum fractures, n (%) | 3 (2.9) | 7 (6.5) | 5 (4.0) | −1.2 (−6.8 to 4.6) | 2.3 (-3.8 to 9.1) |
a
95% confidence interval according to Miettinen.14
b
Some patients had more than one kind of serious or life-threatening visceral damage.
c
Calculated for the patients with rib fractures.