Table 2.
Longitudinal neuropsychological assessment and relationships with Jacobian determinant measures in TBI patients
| Trail Making Task B−A (s) | People Test (total recall) | WASI similarities (score) | Choice Reaction Task median reaction time (ms) | |
|---|---|---|---|---|
| Baseline assessment | ||||
| n | 57 | 57 | 36 | 47 |
| Mean ± SD | 37.9 ± 29.2 | 23.5 ± 7.7 | 36.7 ± 5.0 | 497 ± 102 |
| Grey matter Jacobian determinant | ρ = 0.09, P = 0.49 | ρ = 0.14, P = 0.27 | ρ = 0.36, P = 0.03* | ρ = 0.01, P = 0.94 |
| White matter Jacobian determinant | ρ = 0.01, P = 0.92 | ρ = 0.14, P = 0.29 | ρ = 0.48, P = 0.003** | ρ = −0.11, P = 0.44 |
| Follow-up assessment | ||||
| n | 44 | 44 | 23 | 17 |
| Mean ± SD | 33.1 ± 1 | 25.6 ± 8.8 | 34.7 ± 5.9 | 541 ± 112 |
| Grey matter Jacobian determinant | ρ = 0.07, P = 0.66 | ρ = 0.51, P 0.0004** | ρ = −0.06, P = 0.78 | ρ = 0.43, P = 0.09 |
| White matter Jacobian determinant | ρ = −0.10, P = 0.52 | ρ = 0.48, P = 0.0008** | ρ = 0.04, P = 0.84 | ρ = 0.25, P = 0.34 |
| Longitudinal change | ||||
| n | 41 | 41 | 22 | 16 |
| Mean ± SD | −1.3 ± 29.1 | 2.0 ± 8.2 | −0.05 ± 6.7 | 1.6 ± 163.4 |
| Grey matter Jacobian determinant | ρ = 0.01, P = 0.98 | ρ = 0.36, P = 0.02* | ρ = −0.19, P = 0.39 | ρ = 0.37, P = 0.16 |
| White matter Jacobian determinant | ρ = 0.10, P = 0.51 | ρ = 0.34, P = 0.03* | ρ = −0.26, P = 0.25 | ρ = 0.32, P = 0.22 |
*Significance at P < 0.05. **Significance after FDR correction for 12 independent comparisons. All statistical tests reported are Spearman’s rank order correlations (ρ) and corresponding P-value. WASI = Wechsler Abbreviated Scale for Intelligence. n maximum was 61 for all assessments.