Figure 3.

Time-course of triptolide-induced liver injury. A, Fluorescent images of control and TP exposed fish obtained during time-lapse experiments at the indicated time from start of exposure. B, Relative fold change of fluorescent intensity from baseline during TP exposure with the doses indicated (N = 15 larvae for each dose). C, Box plots (min to max) of histology scores of hepatocyte vacuolation, hepatocyte disarray and hepatocyte swelling during exposure to TP (0.8 µM) for the time durations indicated (control N = 17, 2 h N = 10, 6 h N = 9, 24 h N = 16, 48 h N = 20).