Figure 1.

Intravascular near-infrared fluorescence-optical coherence tomography imaging of fibrin deposition on stents. Rabbits underwent implantation of a 3.5 mm diameter bare metal stent in the aorta. At Day 7, the fibrin molecular imaging agent FTP11-CyAm7 was i.v. injected, followed by near-infrared fluorescence-optical coherence tomography. (A) In vivo 2D near-infrared fluorescence map of stent (upper two rows) and corresponding ex vivo imaging after longitudinally opened (lower two rows). (B) Representative cross-sectional near-infrared fluorescence-optical coherence tomography images at the stent distal edge (i), middle (ii), and proximal edge (iii). (C and D) Histological sections of the proximal stent edge (dotted line in A (i) are shown. Near-infrared fluorescence signal of FTP11-CyAm7 (red) co-localized with fibrin (bright red in Carstairs' staining) and fibrin immunostaining. All scale bars = 1 mm.