Table 2.

Lead SNPs from the fixed-effect inverse variance weighted meta-analysis of the replication cohorts, MDC, PIVUS, ULSAM and MRC Ely. (N_max=4,768)

Trait	Chr	BP*	SNP	EA	OA	Nearest locus	β (mmol/l/yr)	SE (mmol/l/yr)	β L95 (mmol/l/yr)	β U95 (mmol/l/yr)	P	Pheterogeneity	I2
ΔTC	1	62912318	chr1:62912318	C	T	DOCK7/ANGPTL3	−0.003	0.001	−0.005	−0.0004	0.02	0.39	0
ΔTC	8	19669744	rs13282247	T	C	LPL/CSGALNACT1	−0.003	0.001	−0.006	−0.001	0.02	0.39	0
ΔTC	15	40469997	chr15:40469997	A	T	CAPN3	0.012	0.004	0.004	0.021	0.005	0.42	0
ΔTC	16	70636491	chr16:70636491	T	G	HP/HPR	0.011	0.004	0.002	0.02	0.01	0.04	0.69
ΔTC	19	11001703	rs17304534	C	T	LDLR	−0.002	0.001	−0.004	−0.001	0.01	0.99	0
ΔTC	19	50103919	rs7412	T	C	APOE/C1	−0.012	0.002	−0.016	−0.007	1.5 × 10-7	0.81	0
ΔTG	1	62954723	chr1:62954723	C	T	DOCK7/ANGPTL3	−0.002	0.001	−0.004	−0.001	0.004	0.66	0
ΔTG	8	126560154	rs2954029	T	A	TRIB1	−0.003	0.001	−0.004	−0.001	2.4 × 10-4	0.47	0
ΔTG	11	116167789	rs651821	C	T	ZNF159/APOA5/A1	0.008	0.002	0.005	0.011	3.6 × 10-7	0.06	0.60
ΔTG	19	50848859	rs10406431	G	A	GIPR	−0.002	0.001	−0.004	−0.001	0.002	0.6	0
ΔTG	19	50902205	rs11668847	G	T	QPCTL	−0.003	0.001	−0.004	−0.001	0.003	0.13	0.48

β - beta coefficient; β L95 - beta coefficient 95 % confidence interval lower border; β U95 - beta coefficient 95 % confidence interval upper border; BP - basepair position (Build36); Chr - chromosome; N - samples size; EA - effect allele; OA - other allele; SNP - single nucleotide polymorphism, TC - total cholesterol; TG - triglyceride.

^*Build36.

P values are obtained by fixed-effect inverse variance weighted meta-analysis.

Heterogeneity was measured by a Cochran's Q test. P value of this test and I² statistics are reported.