Table 3.
Lipid change associated variants after correction for multiple testing in relation to CAD in the CARDIoGRAMplusC4D consortium. (Nmax=191,650)
| Lipid change meta-analysis |
CARDIoGRAMplusC4D |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Trait | Locus | Chr | BP* | SNP | P | BP* | SNP | C4D OR | C4D P | Category |
| ΔTC | APOE/C1 | 19 | 50103919 | rs7412 | 2.0 × 10-12 | 50087459 | rs2075650 | 1.11 | 5.9 × 10−11 | published for CAD and Δlipids |
| ΔTG | TRIB1 | 8 | 126560154 | rs2954029 | 8.1 × 10-6 | 126560154 | rs2954029 | 1.05 | 4.5 × 10−8 | published for CAD and Δlipids |
| ΔTG | ZNF159/APOA5/A1 | 11 | 116167789 | rs651821 | 1.4 × 10-10 | 116116943 | rs9326246 | 1.09 | 1.5 × 10−7 | published for CAD and Δlipids |
| ΔTC | DOCK7/ANGPTL3 | 1 | 62912318 | chr1:62912318 | 5.2 × 10-4 | 62912318 | chr1:62912318 | 1.00 | NS** | not significant for CAD, novel for Δlipids |
| ΔTC | LPL/CSGALNACT1 | 8 | 19669744 | rs13282247 | 1.7 × 10-4 | 19857460 | rs264 | 1.07 | 5.1 × 10−9 | published for CAD, novel for Δlipids |
| ΔTC | LDLR | 19 | 11001703 | rs17304534 | 1.0 × 10-3 | 11024601 | rs1122608 | 1.10 | 6.3 × 10−14 | published for CAD, novel for Δlipids |
| ΔTG | GIPR | 19 | 50848859 | rs10406431 | 1.7 × 10-4 | 50841458 | rs1029846 | 1.02 | NS** | not significant for CAD, novel for Δlipids |
| ΔTG | DOCK7/ANGPTL3 | 1 | 62954723 | chr1:62954723 | 5.2 × 10-4 | 62912318 | chr1:62912318 | 1.00 | NS** | not significant for CAD, novel for Δlipids |
| ΔTC | CAPN3 | 15 | 40469997 | chr15:40469997 | 1.5 × 10-4 | 40471079 | rs2412710 | 1.14 | 2.4 × 10-4 | novel for CAD and Δlipids |
| ΔTC | HP/HPR | 16 | 70636491 | chr16:70636491 | 2.3 × 10-4 | 70636628 | rs7197453 | 1.04 | 6.1 × 10-5 | novel for CAD and Δlipids |
| ΔTG | QPCTL | 19 | 50902205 | rs11668847 | 2.7 × 10-5 | 50960742 | rs2341097 | 1.03 | 3.5 × 10-4 | novel for CAD and Δlipids |
BP - basepair; C4D - CARDIoGRAMplusC4D; CAD - coronary artery disease; Chr - chromosome; NS - not significant; OR - odds ratio; SNP - single nucleotide polymorphism; TC - total cholesterol; TG - triglyceride.
Build36
Few variants with nominal statistical significance (P∼0.05) in the region
P values are based on linear regression models. SNP associations were tested by fitting the genetic variants (additive model) as the independent variables with follow-up lipid measures as dependent variables.
C4D P values are obtained by a fixed-effect inverse variance weighted meta-analysis in the CARDIoGRAMplusC4D consortium for the top SNPs in the loci associated with lipid changes.