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Pregnancy enhances the toxicological impact of AFB1. The observed increase in phase I metabolic enzymes (CYP1A2, CYP3A) in pregnant mice leads to increased levels of AFB1-epoxide, while amounts of the phase II detoxifying enzyme (GSTA3) remain unchanged. This effect results in enhanced genotoxic stress as measured by the levels of AFB1-N7-Gua adducts, a biomarker of AFB1 exposure.
