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PARP-1 and SOC activation are contiguous and not parallel pathways. HK-2 cells were pre-treated 30 min and co-treated with 2-APB (75 μM) and/or DPQ (20 μM) in the presence of TGHQ 400 μM for 2 h. Cell viability was determined using the MTS based assay. Data are mean ± SE; n ≥ 3. *P < .05 when compared with TGHQ by one-way ANOVA followed by a post-hoc Tukey’s test.
