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. 2017 Aug 14;38(39):2957–2967. doi: 10.1093/eurheartj/ehx454

Figure 3.

Figure 3

Expression of aging and cellular senescence-related genes. Results are expressed as fold regulation vs. old rats injected with phosphate-buffered saline (old-PBS). (A) Significantly up-regulated genes in hearts of young and/or old-CDC animals compared with old-PBS group. (B) Significantly down-regulated genes in hearts of young and/or old-CDC animals compared with old-PBS group. (C) Diagram showing the proportion of differently-regulated genes (only those with significant differences) in young and/or old-CDC treated rats vs. old-PBS animals (62 genes of a total of 168 analysed). Of those 62 genes, 85.5% of the CDC-related changes recapitulated the gene expression pattern observed in young rats. (D) Genes with significant differences in both young and old-CDC rats vs. old-PBS animals. Ns: young rats (n = 4), old-PBS (n = 7), old-CDC (n = 8).