Table 2.
Incidence rates and HRs for hyperglycemia and diabetes after pediatric transplantation, overall and across individual organ transplant groups
| Organ type |
||||||
|---|---|---|---|---|---|---|
| Kidney | Heart | Liver | Lung | Multiple | Overall | |
| Hyperglycemia | ||||||
| Hyperglycemia, n (%) | 17 (11.7) | 16 (12.5) | 19 (12.9) | 10 (45.4) | 5 (55.6) | 67 (14.9) |
| Median days to hyperglycemia (IQR) | 48 (19–186) | 224.5 (42–872) | 26 (18–422) | 141 (35–482) | 28 (23–61) | 52 (22–422) |
| Incidence rate per 100 person-years (95% CI) | 4.4 (2.8–7.2) | 2.9 (1.8–4.8) | 3.5 (2.2–5.4) | 25.2 (13.6–46.9) | 32.3 (13.4–77.6) | 4.4 (3.4–5.6) |
| Unadjusted HR (95% CI) | Ref. | 0.9 (0.4–1.8) | 1.0 (0.5–1.9) | 4.3 (2.0–9.4) | 6.4 (2.4–17.5) | 1.5 (1.2–1.9) |
| Adjusted HRa (95% CI) | Ref. | 1.1 (0.5–2.3) | 1.3 (0.7–2.7) | 4.2 (1.9–9.2) | 8.9 (3.2–25.2) | 1.6 (1.3–2.0) |
| Diabetes | ||||||
| Diabetes, n (%) | 12 (8.3) | 2 (1.6) | 5 (3.4) | 8 (36.4) | 0 | 27 (6) |
| Incidence rate (per 100 person-years) | 3.1 (1.8–5.5) | 0.4 (0.1–1.5) | 0.9 (0.4–2.2) | 20.2 (10.1–40.4) | 1.8 (1.2–2.6) | |
| Unadjusted HR (95% CI) | Ref. | 0.2 (0.0–0.7) | 0.4 (0.1–1.1) | 4.6 (1.9–11.2) | 1.2 (0.8–1.8) | |
| Adjusted HRa (95% CI) | Ref. | 0.3 (0.1–1.4) | 1.0 (0.3–2.9) | 4.5 (1.8–11.1) | 1.5 (1.1–2.1) | |
a
Adjusted for age at transplant and sex. Ref., Reference Group