Table 1.
Patient characteristics, cardiovascular function, and exercise capacity at initial testing in those with and without follow-up testing
| Variable | No follow up | Follow up | P-value | |
|---|---|---|---|---|
| N = 86 | N = 90 | |||
| Age of initial study (years) | 13.0 (3.4) | 11.7 (2.7) | 0 .02 | |
| Gender | Female | 35 (41%) | 28 (31%) | 0 .21 |
| Male | 51 (59%) | 62 (69%) | ||
| Race | White | 74 (86%) | 76 (84%) | 1 .00 |
| Black | 7 (8%) | 8 (9%) | ||
| Other | 5 (6%) | 6 (7%) | ||
| BSA at MRI (m2) | 1.36 (0 .33) | 1.26 (0 .25) | 0 .054 | |
| Subtype of TOF | Stenosis | 71 (83%) | 64 (71%) | 0 .32 |
| Atresia | 12 (14%) | 17 (19%) | ||
| Absent pulmonary valve | 2 (2%) | 7 (8%) | ||
| With atrioventricular canal defect | 1 (1%) | 2 (2%) | ||
| Genotype | Non-syndromic | 61 (71%) | 74 (82%) | |
| Trisomy 21 | 4 (5%) | 4 (4%) | ||
| 22q11.2 deletion | 18 (21%) | 12 (13%) | 0 .12 | |
| Alagille syndrome | 3 (3%) | 0 (0%) | ||
| Staged vs. single repair | Complete repair | 75 (87%) | 72 (80%) | 0 .24 |
| Blalock-Taussig shunt to complete | 7 (8%) | 15 (17%) | ||
| Staged Repair | 4 (5%) | 3 (3%) | ||
| Type of surgical repair | Transannular patch | 57 (66%) | 72 (80%) | 0 .038 |
| Non-transannular patch | 6 (7%) | 7 (8%) | ||
| Ventricular septal defect closure only | 10 (12%) | 2 (2%) | ||
| Right ventricle to pulmonary artery conduit | 11 (13%) | 9 (10%) | ||
| Unknown | 2 (2%) | 0 (0%) | ||
| Cardiovascular function by magnetic resonance imaging | ||||
| Pulmonary valve regurgitant fraction (%) | 33 (17) | 35 (17) | 0 .46 | |
| Indexed right ventricular end diastolic volume (ml/m2) | 110 (41) | 116 (36) | 0 .36 | |
| Indexed right ventricular end systolic volume (ml/m2) | 46 (21) | 48 (19) | 0 .55 | |
| Right ventricular ejection fraction (%) | 61 (9) | 59 (7) | 0 .29 | |
| Right ventricular cardiac index (L/min/m2) | 5.4 (1.4) | 5.6 (1.5) | 0 .38 | |
| Left ventricular ejection fraction (%) | 69 (8) | 69 (7) | 0 .76 | |
| Left ventricular cardiac index (L/min/m2) | 3.6 (0 .8) | 3.6 (0 .7) | 0 .78 | |
| Exercise capacity | ||||
| Minute oxygen consumption at peak exercise (% of predicted) | 76 (19) | 76 (17) | 0 .98 | |
| Minute oxygen consumption at anaerobic threshold (% of predicted) | 86 (17) | 86 (19) | 0 .91 | |
| Maximal work rate (% of predicted) | 82 (23) | 83 (23) | 0 .78 | |
Values are mean (± standard deviation), percentage, or count (%) where appropriate.
BSA, body surface area; TOF, tetralogy of Fallot; MRI, magnetic resonance imaging.