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. 2017 May 26;158(1):213–226. doi: 10.1093/toxsci/kfx082

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© The Author 2017. Published by Oxford University Press on behalf of the Society of Toxicology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Small molecule kinase inhibitors affect human induced pluripotent stem cell-derived cardiomyocytes beating function at concentrations that do not affect cell viability. Changes in beat rate (BR), amplitude (AMP), cell index (CI), and cellular ATP levels expressed as percent control of hiPSC CM treated with 3 µM of compounds for 2 h (BR and AMP) or 24 h (CI and ATP). Points are representative of the mean of at least three independent experiments. Only those compounds that had an effect on BR or AMP are shown.