Table 3.
Correlation of Intragroup Promiscuity and Effect on hiPSC CM Beating Function
| Kinase Group | Enrichment Score | MCC | P-value |
|---|---|---|---|
| CAMK | 2.98 | 0.58 | <0.0001 |
| OTHER | 2.42 | 0.43 | 0.0006 |
| STE | 2.26 | 0.46 | <0.0001 |
| AGC | 2.23 | 0.49 | 0.0002 |
| Atypical | 1.62 | 0.34 | 0.004 |
| CK1 | 1.36 | 0.25 | 0.04 |
| CMGC | 1.35 | 0.26 | 0.04 |
| LIPID | 1.00 | 0.18 | 0.11 |
| TKL | 0.41 | 0.10 | 0.31 |
| TK | 0.18 | 0.04 | 0.53 |
Correlation between CM beating effect and promiscuity within the eight typical kinase groups, the atypical kinase group, and lipid kinase group as described by MCC and ranked by enrichment score.