Table 4.

Effects on iPSC CM Beating Versus Compounds Inactive at All Three Sentinel Kinases for the Training and Testing Sets

	Full Compound Set		Negative at All Three Sentinel Kinases
Functional CM Effect:	% No Effect	% ↓ BR	% No Effect	% ↓ BR
Predicted (training set)	69.4	30.7	96.7	3.4
Observed (testing set)	86.6	13.4	96.4	3.6

Using inactivity at RPS6KB1, FAK, and STK35 as a classifier, 3.6% of compounds observed versus the 3.4% predicted by recursive partitioning analysis of the training set decreased CM beat rate.