Table 4a.

HCV Research UK cohort: summary of epidemiological and clinical data collected for all participants

Category	Major variables captured	Time point
		Enrolment	Follow-up (at least bienially following enrolment)
1: Socio-demographic factors	gender; age; country of birth; ethnicity; recruitment approach; first clinic attendance date	Y	N/A
2: HCV acquisition	route of infection; estimated year of infection, date of HCV diagnosis	Y	N/A
3: Health risk behaviours	data on: alcohol use; drug use; tobacco smoking; and cannabis smoking	Y	Y
4: Physical characteristics	Height, weight, BMI	Y	Y
5: HCV virology	HCV genotype; HCV genotype subtype; viral RNA positivity status; quantitative viral load	Y	Y
6: Comorbid health conditions	presence of: renal failure; diabetes; cancer; depression; HIV co-infection; coagulation bleeding disorder; cryoglobulinaemia	Y	Y
7: Co-medications taken	use of: anti-diabetics, anti-depressants, anti-retrovirals, hypnotics, immunosupressive drugs; opiate substitution therapy; steroids; statins	Y	Y
8: Liver disease status	data on: liver transplantation; liver biopsies performed; diagnosis of cirrhosis; portal hypertension; diagnosis of decompensated cirrhosis; diagnosis of liver cancer; fibroscan scores.	Y	Y
9: Hepatitis C antiviral treatment	data on HCV antiviral treatment episodes including: outcome (i.e. viral clearance), treatment regimen;duration of treatment and side effects.	Y	Y
10: Routine laboratory data	liver function tests; full blood counts; lipid profile tests; blood sugar tests; and renal function tests	Y	N
11. Vital status	data on date and cause of death	N/A	Y

Y= Yes; N=No; N/A = not applicable.