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. 2018 Jan 15;141(2):357–364. doi: 10.1093/brain/awx337

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© The Author(s) (2018). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Enhanced vlPAG functional connectivity in NP+. (A) Group comparison (NP+ > Non-NP) of whole brain functional connectivity strength with the vlPAG seed (from Scan 2) as a function of the background (i.e. ‘resting’) pain intensity ratings (from Scan 2). Voxels within which this relationship was greater in the NP+ group are in red (n = 26; mixed effects: z > 3.1, P < 0.05 cluster corrected). The axial slices show the extent of activation across the whole brain. Radiological convention is used. (B) For clarity, a plot of the correlation between the magnitude of vlPAG functional connectivity and the intensity of the pain at rest reported by NP+ participants is displayed.