Table 1.

Region-based analysis of TRAP1 variants

Group	Number of variants	MAC controls	MAC cases	Burden P-value	SKAT-O P-value	SKAT P-value
The Norwegian ParkWest sample
Non-synonymous	12	18	12	0.407	0.648	0.566
CADD10	11	14	7	0.130	0.221	0.806
CADD15	9	7	4	0.229	0.379	0.751
CADD20	9	7	4	0.229	0.379	0.751
CADD30	2	2	0	0.326	0.489	0.786
Synonymous	2	2	0	0.332	0.746	0.746
The PPMI sample
Non-synonymous	9	5	7	0.279	0.367	0.255
CADD10	8	5	6	0.259	0.382	0.205
CADD15	8	5	6	0.259	0.382	0.205
CADD20	6	4	5	0.293	0.312	0.259
CADD30	2	1	1	0.799	0.277	0.277
Synonymous	2	0	2	0.338	0.739	0.739

CADD = non-synonymous variants with CADD score >10, 15, 20 and 30, respectively.

MAC = minor allele count.

P-values are uncorrected for multiple testing.